diff --git a/ikcp.h b/ikcp.h
index 9421b1c..280603a 100644
--- a/ikcp.h
+++ b/ikcp.h
@@ -238,7 +238,8 @@ typedef struct IQUEUEHEAD iqueue_head;
             defined(__m68k__) || defined(mc68000) || defined(_M_M68K) || \
             (defined(__MIPS__) && defined(__MISPEB__)) || \
             defined(__ppc__) || defined(__POWERPC__) || defined(_M_PPC) || \
-            defined(__sparc__) 
+            defined(__sparc__) || defined(__powerpc__) || \
+            defined(__mc68000__) || defined(__s390x__) || defined(__s390__)
             #define IWORDS_BIG_ENDIAN 1
         #endif
     #endif